This site uses cookies to improve your browsing experience. By using this site, you agree to their use. Cookie Policy

LUX-Lung 8 Clinical Data
XOVOLTIB® showed superior OS versus erlotinib in patients with unselected squamous NSCLC after chemotherapy1

LUX-Lung 8: OS (key secondary endpoint)

  • 19% relative reduction in the risk of death versus erlotinib (HR=0.81; P=0.0077)1
  • The survival benefit was evident from the first pre-specified time point measured at 6 months and maintained at 18 months1
  • OS benefit consistent across clinically relevant subgroups1
  • OS unlikely to have been affected by subsequent therapies, as a similar proportion of patients in both arms received additional treatment(s)1

CI=confidence interval; HR=hazard ratio; NSCLC=non-small cell lung cancer; OS=overall survival.

XOVOLTIB® significantly increased PFS versus erlotinib in patients with unselected squamous NSCLC after chemotherapy1

LUX-Lung 8: PFS by independent review at time of OS analysis (2015) (primary endpoint)

  • 19% reduction in relative risk of disease progression versus erlotinib (median 2.6 months vs 1.9 months [HR=0.81; 95% CI, 0.69–0.96; P=0.0103])1

CI=confidence interval; HR=hazard ratio; NSCLC=non-small cell lung cancer; PFS=progression-free survival.

XOVOLTIB® improved cough and quality of life versus erlotinib in squamous NSCLC following chemotherapy1

LUX-Lung 8: improvement in symptoms

  • More patients had improved overall health-related quality of life with XOVOLTIB® than with erlotinib (36% vs 28%; P=0.041)1
  • Patients on XOVOLTIB® had significantly better mean EORTC scores for cough compared to erlotinib over time1
  • XOVOLTIB® also significantly delayed deterioration of dyspnoea (median 2.6 months vs 1.9 months [HR=0.79; 95% CI, 0.66– 0.94; P=0.0078]) with favourable trends noted in delaying deterioration of cough and global health status/quality of life1

Rationale for targeting ErbB in squamous NSCLC

 

Squamous NSCLC is characterised by a high mutation rate and complex genomic alterations. Nevertheless, a comprehensive genomic analysis of 178 tumours by the Cancer Genome Atlas Research Network identified a potentially targetable gene or pathway alteration in 96% samples studied. Multiple genes and pathways are affected, including alterations in the ErbB family of receptors and their associated signalling pathways. Genomic analysis has identified potential oncogenic drivers in SCC, including ErbB family, FGF receptor (FGFR) family, PI3K pathway and DDR2.2 

CI=confidence interval; EGFR M+=epidermal growth factor receptor mutation positive; EORTC=European Organisation for Research and Treatment of Cancer; HR=hazard ratio; HRQoL=health-related quality of life; NSCLC=non-small cell lung cancer.


You may be interested in:

Is this information compelling to you?

References

  1. Soria JC et al. Lancet Oncol. 2015;16(8):897-907.
  2. Heist RS et al. J Thorac Oncol. 2012;7(5):924–33.
  1. [1] Sequist LV et al. J Clin Oncol. 2013;31(27):3327-3334.

  2. [2] Wu YL et al. Lancet Oncol. 2014;15(2):213-222.

  3. [3] Yang JC et al. Lancet Oncol. 2015;16(2):141-151.

  4. [4] Park K et al. Lancet Oncol. 2016;17(5):577-589.

  5. [5] Soria JC et al. Lancet Oncol. 2015;16(8):897-907.

  6. [6] Solca F et al. J Pharmacol Exp Ther. 2012;343(2):342-350.

  7. [7] Yang JC et al. J Clin Oncol. 2013;31(27):3342-3350.

  8. [8] Hirsch V et al. Poster #369 presented at: American Society of Clinical Oncology (ASCO) Annual Meeting; Chicago, IL, USA; 3-7 June 2016.

  9. [9] Yang JCH et al. Ann Oncol. 2016;27(11):2103-2110.

  10. [10] Schuler M et al. J Thorac Oncol. 2016;11(3):380-390.

  11. [11] Paz-Arez L et al. Ann Oncol. 2017; 28(2):270-277

  12. [12] XOVOLTIB® Local pack insert version dated 21st July 2017

In case you come across any adverse events related to our products, please report it to PV team immediately.
Phone: +91 9819241697
Email: PV_local_India@boehringer-ingelheim.com

For any query on Boehringer Ingelheim India's product or therapy area, kindly contact
Phone: 1800227887
Email: medical.query.mum@boehringer-ingelheim.com

Back to top